This innovative program will bring the forefront of cancer science to Africa and will appeal to a broad spectrum of cancer researchers—from laboratory scientists to physicians in all disciplines of the cancer field. As part of AACR’s international efforts; the meeting will feature talks from leading basic, translational, and clinical researchers across the hottest areas in cancer research. The program will also feature several sessions dedicated to cancers that have a high rate of incidence in Africa and supplement international speakers with experts throughout the region. We anticipate that this meeting will be historic in its impact and will attract 300 attendees – most of who will be working from Africa or have collaborations/connections to research being conducted in Africa. In addition to the disease sites of particular interest to local researchers and clinicians, the program will feature sessions on DNA repair, epigenetics, genomic medicine, immunotherapy, molecular targets, prevention, and viruses and cancer.