Epigenetics impacts human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have documented mutations, altered expression and copy number alterations in numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide data has also illustrated the relationship between altered epigenetic states (e.g., modified DNA and histones) and disease onset and progression. Therefore, there is a need to discover the molecular mechanisms and interplay between epigenetic regulators. These mechanistic insights will shed light on the impact epigenetic regulators have on cellular homeostasis, while resolving their pathogenic contribution to disease states. This meeting is aimed at interrogating the most current knowledge surrounding the epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to developmental and disease models. In addition, this meeting will highlight the impact that preclinical and clinical epigenetic therapeutics have on a panel of diseases including cancer and neurological disorders. By presenting these various aspects associated with epigenetics and diverse disease, this unique forum should promote dynamic discussions, interactions and collaborations that will impact our understanding of disease and possible treatment strategies. Opportunities for trainee career development, networking and oral presentations are provided by a “Focus on Junior Scientists” session, a panel discussion and mixer with scientific editors and another with industry scientists.