Understanding the interactions between materials and the host immune systems lays the foundation for biomaterial design. Significant progress has been made in the field in the past few years, ranging from developing biomaterials to resist the foreign body response and camouflaging nanoparticles to avoid immune recognition to actively modulating cell phenotypes and inducing antigen-specific immune responses in a highly efficient manner. This symposium will cover a broad topics from fundamental material-immune cell interactions to translational applications of materials in immunotherapy. Symposium attendees with broad science, engineering and biomedical expertise can expect to be exposed to state-of-the-art developments in this fast growing interdisciplinary area.