KEeH’15 will bring researchers, developers, practitioners, and users to present their latest research, results, and ideas in all areas of knowledge engineering, machine learning and artificial intelligence in medicine and health care.KEeH’15 will provide a forum for the exchange of ideas between physicians and computer scientists, and knowledge engineers to address the important issues in those areas. Papers related to methodologies, techniques and applications in bio-medical informatics, telemedicine, and eHealth are especially solicited.