The IEEE International Conference on Bioinformatics and BioEngineering (BIBE) is a premier international research forum which stimulates and fosters the exchange of ideas for Bioinformatics and Bioengineering research and applications. This year’s conference solicits original research findings, engineering designs, practical development experiences, and discussions of real-world systems. Representative issues to be addressed include, but are not limited to: Computational Systems Biology Microarry Data Analysis Gene Regulation, Network, and Pathway Analysis Identification and Classification of Genes Protein Structure Prediction Molecular Structures, Functions, and Evolution Next-Gen Sequencing and Metagenomics Protein/RNA Structure, Function, and Interactions Functional Genomics and Proteomics Molecular Evolution and Phylogeny BioMedical and Health Informatics Biomedical Signal Analysis and Modeling Bio-Imaging, Sensing, and Data Fusion. Biomarker Discovery Healthcare Data Acquisition, Analysis, and Modeling BioMedical Data Knowledge Extraction Biomedical Data Integration, Modeling, and Preprocessing Biological Data Mining, Knowledge Sharing, Visualization, and Knowledge Utilization Biomedical Data Mining Systems and Computing Platforms Electronic Health Record Acquisition, Analysis, and Decision Support High Performance Computing for Biomedical Data Analysis Smart Clinical Diagnosis and Decision Systems Biomedicine, Biotechnology, and Pharmacology Drug Discovery and Development Biochemical and Medicinal Chemistry Computer-Aided Drug Design Clinical Trials and Observational Studies Bioengineering Models and Systems Engineering Models in Bio-Medicine Cell and Tissue Engineering Medical Robotics, Surgical Planning, and Biomechanics Computer Assisted Intervention Systems