It is my great pleasure to invite you to attend and contribute to the 42nd Symposium of HPLC which will be held, June 21-25, 2015 at the International Conference Center Geneva (CICG) in Geneva, Switzerland. The HPLC series since its first edition in 1973 in Interlaken, Switzerland, has established itself as one of the leading conference in analytical chemistry and in particular in the field of separations sciences and related topics. The emphasis of the meeting will be around fundamentals aspects of separations sciences, sample preparation, novel developments and applications as well as hyphenation with mass spectrometry. The meeting is structured with courses, tutorials, workshops, general and parallel sessions packed with plenary, keynote, invited and contributed talks from academic, government, and industrial scientists. The poster sessions, including the best poster awards, are a key part of the meeting allowing young and established researchers from all over the world to discuss their latest results. Besides the core scientific program, the symposium will host a large and comprehensive exhibition where companies active in the field will present their latest developments in instrumentation, software and applications related to sample preparation, separation and detection illustrated in technical seminars. Geneva is located in the middle of Europe and in one of the major gates to Switzerland easily accessible from all over the world. The city, at the end of Leman Lake, as a strong international flavor and offers many possibilities in culture, cuisine, history and science. HPLC 2015 – Geneva should be the conference where latest developments in all types of liquid-phase separations are presented and discussed in scientific sessions as well during the social events allowing fruitful exchanges and networking in a highly motivated l and friendly environment.