With an emphasis on the applications of computer, physical, engineering and mathematical models for solving modern challenging problems in life sciences, the fourth event CMLS-13 aims to bring biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of computational life sciences. A goal of this meeting is that the interactions of scientists across several disciplines will lead to the identification of new scientific investigations, shape future directions for strategic research, and help industrial users apply advanced computational techniques for solving practical life science problems. As another important aspect, CMLS-13 aims to provide opportunities for postgraduate research students to present latest research results and establish links with experts across several scientific disciplines. CMLS-13 will consist of invited talks by leading international experts in computational life sciences, contributed papers, and social programs.