System Science and Engineering has emerged as a research field that covers a wide spectrum of modern technology. A system can be considered as a collection of entities and their interrelationships gathered together to form a whole greater than the sum of the entities. It also involves with people, organizations, cultures, activities and interrelationships among them. While systems composed of autonomous subsystems are not new, increased data density, connectivity and ubiquitous computational resources have increased their interdependence and interaction complexity. This has in turn made the already difficult job of planning, developing and deploying complex systems even more difficult. Technology advancement not only provides opportunities for improving system capabilities but also introduces development risks that must be weighed and managed. Thus, it is our goal to bring together scholars from all areas to have a forum to discuss, demonstrate and exchange research ideas in the scope of system science and engineering.