This Keystone Conference, entitled “Cardiac Remodeling, Signaling, Matrix and Heart Function” will highlight recent scientific advances in cardiac biology and heart failure research and relate these insights to the development of novel clinical therapeutics that may impact patient care. This 2013 meeting will bring together both academic and industrial scientists employing state-of-the-art technologies encompassing the fields of stem cell science, tissue regeneration, bioengineering, non-coding RNAs, human and animal genetics, calcium signaling, autophagy and proteolysis, cardiac mechanics, and cardiac matrix biology. The translation of basic scientific discovery to pre-clinical drug development will be emphasized. In addition, there will be a workshop that details recent advances in development of novel therapeutic agents to treat heart failure and arrhythmias. This Keystone Conference is organized to provide scientists with diverse areas of expertise knowledge of technological applications and biological insights about the development and pathophysiology of cardiac dysfunction and arrhythmias. This 4-day conference is designed for a wide audience of academic and industrial basic, translational and clinical scientists. Interaction between scientists will be promoted through lectures, poster sessions, informal discussions and workshops.