Obesity and Type 2 Diabetes associate with a disruption in energy, glucose and lipid homeostasis. New exciting developments continue to indicate a key role for the Central Nervous System in the homeostatic control of systemic metabolic processes and ultimately body weight. A goal of this meeting is to bring together basic and clinical scientists from academia and the pharmaceutical industry studying neuronal control of appetite, metabolism and body weight or related complementary fields such as addiction/reward, cellular stress or inflammation) to share novel and relevant insights with relevance for human obesity, diabetes and metabolic disease. The meeting seeks to trigger progress towards a novel and improved model, which integrates existing knowledge with novel discoveries on central nervous system mechanisms activated by hormones or nutrients that regulate systemic metabolism in order to provide the research in this field with a valuable new tool with combined relevance for both basic science and clinical research.