The 2018 STIM GRC will explore recent advances in understanding fundamental mechanisms, pathways and systems in microbial signal transduction. Focus will be placed on bacterial receptors and cognate intracellular networks that involve phosphorelays, signaling by cyclic nucleotides, reactive metabolites and quorum sensing. Topics will include gene regulation by sensory input, the assembly and regulation of motility apparatuses, chemotaxis, energy monitoring, community behavior, quorum sensing, biofilm formation, regulation of pathogenicity, and interactions with the host. These areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging and biophysical approaches. Emerging directions, such as the engineering of signaling networks, will be explored. Invited speakers will include both established and early-stage investigators. In addition, poster presenters will compete for short late-breaking topic talks. We will also host a Gordon Research Seminar (GRS) for postdocs and graduate students to precede the GRC meeting. Participants will enjoy the Conference's open and collegial atmosphere that provides valuable opportunities to engage in scientific discussion and foster interdisciplinary collaboration.