The 1st International Conference on Applications of Intelligent Systems, APPIS 2018, with tutorials will be held on 8-12 January 2018 in Las Palmas de Gran Canaria, Spain. The main conference will be on 10-12 January, the tutorials will be on 8, 9 and 13 January. APPIS 2018 is organized by the University of Groningen and the University of Las Palmas de Gran Canaria. APPIS 2018 aims at bringing together scientists who develop or apply intelligent systems, machine learning, artificial intelligence, pattern recognition, and related methods. The program of APPIS includes a workshop on Cognitive Computing in Medicine, COCOMED 2018.