The Fourth International Workshop on Computational Network Biology: Modeling, Analysis, and Control (CNB-MAC 2017) will be held in Boston, MA, August 20. The workshop will be organized in conjunction with the 8th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM-BCB 2017), the flagship conference of the ACM SIGBio. The workshop aims to provide an international scientific forum for presenting recent advances in computational network biology that involve modeling, analysis, and control of biological systems and system-oriented analysis of large-scale OMICS data. CNB-MAC 2017 solicits original research papers that report new research findings that have not been published elsewhere, highlights that present advances in the field that have been reported in recent journal publications, and poster abstracts for rapid dissemination of the latest research results in computational network biology. The main emphasis of the workshop will be on rigorous mathematical/computational approaches for studying biological networks, systems, and pathways and the analysis of large-scale OMICS data from a systems perspective.