Distributed systems and middleware are at the epicenter of large scale data centers, cloud computing infrastructures, and scalable web services. The 10th Workshop on Large Scale Distributed Systems and Middleware (LADIS 2017) aims to bring together a select group of researchers and professionals in the field to surface their work in an engaging workshop atmosphere. LADIS 2017 will take place in conjunction with EuroSys on April 23-26 in Serbia.