In this paper, a new method based on generalized regression neural network is proposed for the control of multi-effectors aircraft. The generalized regression neural network has the advantages of simple design, fast convergence and so on, and is widely used in the control system. When the aircraft malfunction, it is necessary to control the distribution of the aircraft after the fault is diagnosed. Change the use of the operating surface, reduce the use of the fault surface, the use of normal operating surface to control the impact of the fault plane to maintain normal flight.