In this paper we present a co-evolutionary algorithm integrated with immune multi-agent based on analyzing the lack of the immune evolutionary algorithms and co-evolutionary algorithm.First,antibody deputies are generated through the competition among populations and within populations sort and based on the calculation target of antibody information entropy and affinity,then the algorithm searches the optimal solution is implemented through affinity maturation and Gene library update evolution.The simulation results show that the algorithm has a good search capability of the optimal solution,calculation accuracy and convergence rate is superior to the traditional algorithm.