Aerobic composting has been widely implemented as an effective bioprocess for the treatment and resource recovery of organic solid waste. Given aerobic, anoxic and anaerobic conditions inside composting piles, organic mineralization in terms of nitrogen, carbon, and sulphur gases occur to reduce the environmental benefits of composting and nutrient contents in the final product. As such, massive studies have been conducted to regulate organic mineralization toward humification to enhance compost quality for biofertilizer application. In this study, we reported our recent studies on the development of hybrid strategies, including feedstock formulation, process optimization, and functional additives, to simultaneously reduce gaseous emissions and enhance humus content, thereby achieving the transformation of organic mineralization to humification. Furthermore, advanced sequencing technique was used to track microbial dynamics in response to different regulation strategies in composting. Thus, results from this study could improve the composting of organic solid waste for resource recovery and environmental protection.