12 / 2021-10-08 19:49:04

Ruthenium β-carboline complexes induce apoptosis and autophagy in HeLa cell

Ruthenium β-carboline complexes,apoptosis,autophyagy

Marine natural products are an important source of anti-tumor active compounds. β-carboline alkaloids are a large class of natural and synthetic indole alkaloids, which are widely distributed in many plants and marine organisms. In addition to neuropharmacological effects, β-carboline alkaloids also have significant anti-tumor activities, such as inserting DNA, inducing cell apoptosis, and anti-angiogenesis ^[1]. Tan et al. synthesized a series of iridium complexes with β-carboline as the main ligand. In vitro activity tests showed that these complexes could well inhibit the proliferation of tumor cells and showed superior anti-tumor activity compared with cisplatin and β-carboline ^[2]. Therefore, the formation of metal complexes with β-carboline ligand is an effective way to find novel anti-tumor drugs.