87 / 2023-09-26 09:30:18

Spatially Constrained Phosphinidene: Experimental and Theoretical Studies

organophosphorus; spatial constraint; phosphinidene

Phosphorus in Synthetic Chemistry > 1) Phosphorus compounds as catalysts

As one of important low-coordinated organophosphorus species, transient electrophilic phosphinidenes¹ keeps attracting enormous interest. Extensive effort has been devoted to understanding the reactivity of this low-coordinated species, but controlling the reaction pathway hampered by the high reactivity of this transient species. Our recent results demonstrate that the "spatial constraint" strategy can provide opportunities for the chemistry of phosphinidene by unlocking unconventional reaction pathways.  For example, spatial constraint blocks the well-known [1+2] cycloaddition of electrophilic phosphinidene and enables C-H ² or C-C ³ bond activation. This strategy also opens up new avenues for designing and constructing highly reactive organophosphorus intermediate through structural resonance.^4-5