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Phosphorus(V) complexes of porphyrazines and corrolazines as pH-switchable fluorophores

Phosphorus(V) complexes; Porphyrazines; Corrolazines; Fluorophores; Photosesitizer

Phosphorus Chemistry and Life & Health science > 1) Phosphorus chemistry in chemical biology

Coordination of phosphorus(V) as a central atom endows tetrapyrrolic macrocycles such as porphyrins, phthalocyanines and their contracted analogues (corroles and corrolazines) with peculiar spectral-luminescence and photophysical properties determining their application perspectives in medicine and organic electronics. We have prepared the series of P^V complexes of porphyrazines, corrolazines and tetrapyrazinocorrol­azines bearing eight peripheral phenyl or 2-pyridyl groups, as well as their water-soluble sulfonated or quaternized derivatives [1,2].



Fig. 1

Corrolazine complexes are good fluorophores and exhibit enhanced photosensitizing ability, also in water solutions. We have demonstrated that ligands attached to the P^V atom in the axial positions (hydroxy, or aryloxy groups) allows the control the photophysical properties by modulation of the medium acidity. This can be used for development of pH-switchable photosensitizers and fluorophors for bioimaging.

Acknowledgement. This work was supported by Russian Foundation of Basic Research (№ 20-53-26004) and Russian Science Foundation (№ 17-13-01522).

Keywords：Phosphorus(V) complexes; Porphyrazines; Corrolazines; Fluorophores; Photosesitizer

Reference

[1] Ivanova, S.S., Salnikov, D. S.; Knorr, G.; Ledovich, O.; Sliznev, V.; Kubát, P.; Novakova, V.; Stuzhin, P. A. Dalton Transactions 2022, 51, 1364-1377.

[2] Lazovskiy, D. A.; Skvortsov, I., Novakova, V.; Stuzhin, P. A. Dalton Transactions 2022, 51, 5687-5698.