30 / 2021-06-27 17:23:55

Preparation of Single-atom Nanozyme Pt@MoS2 Synthesized by Ion Implantation of Platinum Ions and Research on Cancer Treatment

Single-atom nanoenzyme,Ion implantation,Cancer treatment

Molybdenum is an essential trace element for the human body and one of the seven important micronutrient elements. Compared with the similar transition elements, molybdenum has very low toxicity, even can be considered as basically non-toxic. In recent years, the use of molybdenum disulfide to synthesize new biomedical materials has attracted widespread attention.^[1] Based on this, we synthesized a single-atom nanoenzyme (Pt@MoS₂) using ion implantation technology. Due to its unique chemical properties, molybdenum disulfide can avoid the precipitation of toxic metal ions and the human body can maintain the balance of molybdenum through kidney metabolism. Popcorn hollow molybdenum disulfide was prepared by mixing ammonium molybdate [(NH₄)₆Mo₇O₂₄·4H₂O] and potassium thiocyanate (KSCN) at high temperature. In order to improve the antibacterial and biocompatibility of molybdenum disulfide, platinum ions were implanted by surface modification, which showed good effect in cancer treatment. Using electron paramagnetic resonance spectrometer, confocal laser scanning microscope and scanning electron microscope, the radical identification, cytoplasmic localization and surface morphology analysis of single-atom nanozyme (Pt@MoS₂) were carried out. The corrosion resistance of the material was tested under simulated body fluid conditions, and the effect of platinum content on the antibacterial properties of the material was evaluated through in vitro antibacterial experiments. In vitro cytotoxicity test experiments show that single-atom nanozyme (Pt@MoS₂) has a certain inhibitory effect on the reproductive passage of mouse breast cancer cells (4T1).