This study describes an integrated model platform for assessing the interaction among land use, transportation, and mobile source emissions. In the proposed integrated framework, LandSys, a home grown land use model, produces land use change over the space and time dimensions, allocates land use forecast results in terms of household and employment at the traffic analysis zone (TAZ) level, and feeds these socioeconomic data into a travel demand model, Florida Standard Urban Transportation Model Structure (FSUTMS). Then, the produced travel time and accessibility index by FSUTMS are fed back into LandSys to quantify the emission. Finally, the emission from standalone FSUTMS and integrated framework are compared to quantify the air quality benefits of the land use development from the integrated land use and transportation model. In the case application of Orange County, FL in 2000, 2012 and 2025, five major indicators of transportation networks were used: link saturation in the transportation network, overall vehicle miles traveled (VMT), vehicle hours traveled (VHT), mobile source greenhouse gas emission and fuel consumption. The results show that the values of five indicators are lower in the results of integrated platform than those predicted by standalone FSUTMS models, which implies the effectiveness in environment improvement under the considerations of interaction between land use and transportation.