580 / 2019-04-11 20:06:05

Eudicot-specific sphingolipids determine host selectivity of microbial NLP cytolysins

NEP1-like proteins, toxin, effector, sphingolipid, GIPC

全体主题 > Plant Microbe Interactions & Microbiomes

Necrosis and ethylene-inducing peptide 1-like (NLP) proteins compose a superfamily of proteins produced by plant pathogenic bacteria, fungi and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Dicot plant-specific glycosylinositol phosphorylceramide (GIPC) sphingolipids, serve as NLP toxin receptors mediating ion pore formation, membrane insertion and host cell lysis (1). Resistance of monocot plants to NLP cytolysins may be due to the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in the NLP cytolysin mechanism that determine plant clade-specific toxin selectivity and propose the use of NLPs as naturally occurring dicot weed herbicides.


REFERENCES
1. Lenarcic T, Albert I, Böhm H, Hodnik V, Pirc K, Zavec AB, Podobnik M, Pahovnik D, Zagar E, Pruitt R, Greimel P, Yamaji-Hasegawa A, Kobayashi T, Zienkiewicz A, Gömann J, Mortimer JC, Fang L, Mamode-Cassim A, Deleu M, Lins L, Oecking C, Feussner I, Mongrand S, Anderluh G, Nürnberger T. Eudicot-specific sphingolipids determine host selectivity of microbial NLP cytolysins. Science 358: 1431-1434 (2017)