82 / 2018-06-07 15:07:26

Fused Extrusion Additive Manufacturing of Polycaprolactone–Magnesium Composite for Bone repairation

Polycaprolactone,Magnesium,mechanical properties,degradation,material extrution

全体主题 > vi. BAMOS (Biomaterials and Additive Manufacturing: Osteochondral Scaffold innovation)

Polycaprolactone (PCL) and magnesium (Mg) both two kinds of materials have a long history in the biomedical application area. PCL and Mg both are biodegradable and bioresorbable as well as PCL is a FDA approved polymer and Mg element mainly exists in the bone system helping bone strengthen and grow. However, the low me-chanical strength with intrinsic hydrophobic properties of PCL and the rapid corrosion with hydrogen evolution in the human body fluid of Mg limit their use in bone substi-tutes. Our group incorporated Mg micro-particles into the PCL matrix after which producing PCL/Mg composite filament for material extrusion. The tensile, bending and compression samples are made to verify the influence of printing perimeters to the mechanical properties of PCL/Mg with a consequence of 60%-80% improving in the flexible modulus which is closing to those of human cancellous bone and 11%-25% improving in the bending strength comparing to the pure PCL. Using the material ex-trusion technology, we fabricate the bone tissue engineering scaffolds with the pore size of 300μm-500μm and strut size of 600μm which is appropriate to the cell growth and customized dog mandible prosthesis with 20% and 100% infill rate. The PCL/Mg scaffold has a faster degradation time than the pure PCL and released Mg2+ is benefit to the cell proliferation and differentiation. The SEM images show a rougher surface morphology in contrast to the pure PCL with Mg micro-particles inserted on the PCL matrix surface indicating that the improvement of hydrophilicity which is contribute to cell attachment and growth.