63 / 2018-07-30 13:09:45

Controlled release of naringin in metal-organic frameworks (MOFs) loaded mineralized collagen coating to simultaneously enhance osseointegration and antibacterial activity

MOFs,naringin,controlled release,antibiosis,osteogenesis

全体主题 > ii. Biomaterials and formulation of novel “bioinks” for tissue-specific applications

Titanium implants have been applied widely in plastic surgery or oral implantation because of their biocompatibility. Aseptic loosening usually originates from excessive mechanical loading, the formation of nanocrystals from implants wearing that results in inflammation and resorption of the bone, and inferior osseointegration. On the other hand, bacteria (most prominently Staphylococcus bacteria) can infect an implant surface and produce a stubborn biofilm, thereby leading to implant failure. Here we fabricate a synthetic coating, using naringin, a Chinese herbal medicine, which can promote the secretion of bone morphogenetic proteins (BMPs), enhance the proliferation and osteoblast differentiation of bone marrow stromal cells and has antibacterial ability, metal-organic frameworks (MOFs), ideal drug carriers. we evaluated the osseointegration and antibacterial performance of naringin-loaded mineralized collagen coatings with the aid of MOF nanocrystals. The MOF nanocrystals were synthesized by a hydrothermal method. Mineralized collagen coatings were deposited on a metal titanium surface using electrochemical deposition. The adhesion, proliferation, and osteoblastic differentiation of the MSCs cultured on the coatings were observed to estimate their bioactivity. Osteogenesis induced at 21 days was evaluated to detect the mineralization intensity of the MSCs. The antimicrobial activity against S. aureus of the coatings was demonstrated. Further, the possible signaling pathway of the naringin-enhanced osteogenesis and antibacterial activity were also discussed.